.dpef-wrap{--blue:#0b3b78;--blue2:#145da0;--yellow:#f5c542;--ink:#172033;--muted:#64748b;--line:#dbe4ef;--bg:#f6f9fc;max-width:1120px;margin:28px auto;font-family:Arial,Helvetica,sans-serif;color:var(--ink);line-height:1.55}.dpef-wrap *{box-sizing:border-box}.dpef-hero{background:linear-gradient(135deg,#082f63,#145da0);color:#fff;border-radius:24px;padding:34px 38px;display:flex;justify-content:space-between;align-items:center;gap:28px;box-shadow:0 16px 40px rgba(11,59,120,.18)}.dpef-kicker{font-size:12px;font-weight:800;letter-spacing:.12em;color:#ffe18a}.dpef-hero h1{font-size:clamp(34px,5vw,58px);line-height:1.02;margin:8px 0 12px;color:#fff}.dpef-hero p{font-size:18px;max-width:680px;margin:0;color:#edf6ff}.dpef-hero-badge{display:grid;grid-template-columns:repeat(2,64px);gap:8px;flex:0 0 auto}.dpef-hero-badge span{width:64px;height:64px;border-radius:18px;background:rgba(255,255,255,.14);border:1px solid rgba(255,255,255,.22);display:grid;place-items:center;font-size:29px;font-weight:900}.dpef-hero-badge span:first-child,.dpef-hero-badge span:last-child{background:var(--yellow);color:#17345c;border-color:transparent}.dpef-note{margin:18px 0;background:#fff7d6;border:1px solid #f0d36e;border-radius:14px;padding:14px 18px;color:#604d00}.dpef-form{background:#fff;border:1px solid var(--line);border-radius:20px;padding:24px;box-shadow:0 8px 24px rgba(15,23,42,.05)}.dpef-grid{display:grid;grid-template-columns:1fr 1fr;gap:16px}.dpef-field{position:relative;border:1px solid var(--line);border-radius:16px;padding:18px;background:#fbfdff;display:block}.dpef-field:focus-within{border-color:#78aee3;box-shadow:0 0 0 3px rgba(20,93,160,.09)}.dpef-letter{position:absolute;top:15px;left:16px;width:34px;height:34px;border-radius:10px;display:grid;place-items:center;background:var(--blue);color:#fff;font-weight:900}.dpef-label{display:block;padding-left:46px;margin-bottom:12px}.dpef-label strong{display:block;font-size:16px}.dpef-label small{display:block;color:var(--muted);font-weight:400;margin-top:2px}.dpef-field textarea{display:block;width:100%;min-height:86px;border:1px solid #cfd9e6;border-radius:12px;padding:12px 13px;font:inherit;background:#fff;resize:vertical;color:var(--ink)}.dpef-field textarea:focus{outline:none;border-color:var(--blue2)}.dpef-filter-section{margin-top:20px;border:1px solid #d9e4f0;border-radius:18px;background:linear-gradient(180deg,#fff 0%,#fbfdff 100%);padding:20px;box-shadow:0 8px 24px rgba(15,23,42,.035)}.dpef-filter-heading{display:flex;align-items:flex-start;justify-content:space-between;gap:12px;margin-bottom:16px}.dpef-filter-heading strong{display:block;color:var(--blue);font-size:16px;line-height:1.3}.dpef-filter-heading span{display:block;color:var(--muted);font-size:13px;margin-top:2px}.dpef-filters{display:grid;grid-template-columns:minmax(230px,1.5fr) minmax(140px,.75fr) minmax(140px,.75fr) minmax(190px,1fr);gap:14px;margin:0}.dpef-filter-field{display:block!important;min-width:0;margin:0!important}.dpef-filter-field>span{display:block!important;font-size:13px!important;font-weight:800!important;line-height:1.25!important;color:#24324a!important;margin:0 0 7px!important;padding:0!important}.dpef-wrap .dpef-filter-field select,.dpef-wrap .dpef-filter-field input[type=number]{display:block!important;width:100%!important;max-width:none!important;height:50px!important;min-height:50px!important;margin:0!important;border:1px solid #cbd8e6!important;border-radius:12px!important;background:#fff!important;padding:0 14px!important;color:var(--ink)!important;font:inherit!important;font-size:15px!important;line-height:1!important;box-shadow:0 1px 2px rgba(15,23,42,.02)!important;outline:none!important}.dpef-wrap .dpef-filter-field select:focus,.dpef-wrap .dpef-filter-field input[type=number]:focus{border-color:#72a9dc!important;box-shadow:0 0 0 3px rgba(20,93,160,.10)!important}.dpef-checks{display:grid!important;grid-template-columns:repeat(3,minmax(0,1fr));gap:12px!important;margin:18px 0 0!important;padding:16px 0!important;border-top:1px solid #e3ebf4;border-bottom:1px solid #e3ebf4;color:#334155}.dpef-wrap .dpef-check{display:flex!important;align-items:center!important;justify-content:flex-start!important;gap:10px!important;min-width:0!important;margin:0!important;padding:11px 12px!important;border:1px solid #e2e9f1;border-radius:12px;background:#fff;cursor:pointer;font-size:14px!important;line-height:1.35!important;color:#334155!important}.dpef-wrap .dpef-check:hover{border-color:#b8cde2;background:#fafdff}.dpef-wrap .dpef-check span{display:block!important;min-width:0!important;margin:0!important;padding:0!important;white-space:normal!important}.dpef-wrap .dpef-check input[type=checkbox]{-webkit-appearance:auto!important;appearance:auto!important;display:inline-block!important;position:static!important;float:none!important;width:20px!important;min-width:20px!important;max-width:20px!important;height:20px!important;min-height:20px!important;max-height:20px!important;flex:0 0 20px!important;margin:0!important;padding:0!important;vertical-align:middle!important;accent-color:var(--blue2);box-shadow:none!important}.dpef-actions{display:flex!important;flex-wrap:wrap;gap:12px!important;align-items:center!important;margin-top:2px}.dpef-actions button,.dpef-copy,.dpef-card-actions button{font:inherit;cursor:pointer}.dpef-actions button{min-height:48px}.dpef-primary,.dpef-secondary{display:inline-flex!important;align-items:center!important;justify-content:center!important;gap:9px!important}.dpef-primary svg,.dpef-secondary svg{width:20px;height:20px;fill:none;stroke:currentColor;stroke-width:2;stroke-linecap:round;stroke-linejoin:round;flex:0 0 auto}.dpef-primary{border:0!important;background:linear-gradient(180deg,#ffd44f 0%,#f5c542 100%)!important;color:#10386d!important;font-weight:900!important;padding:13px 22px!important;border-radius:12px!important;box-shadow:0 4px 0 #d7a900,0 8px 18px rgba(215,169,0,.15)!important;transition:transform .15s ease,box-shadow .15s ease}.dpef-primary:hover{transform:translateY(-1px);box-shadow:0 5px 0 #d7a900,0 10px 20px rgba(215,169,0,.18)!important}.dpef-secondary{border:1px solid var(--blue2)!important;background:#fff!important;color:var(--blue2)!important;font-weight:800!important;padding:12px 18px!important;border-radius:12px!important;box-shadow:0 1px 2px rgba(15,23,42,.03)!important}.dpef-secondary:hover{background:#f3f8fe!important}.dpef-linkbtn{border:0!important;background:transparent!important;color:var(--blue2)!important;font-weight:700!important;padding:10px 12px!important;border-radius:10px!important}.dpef-linkbtn:hover{background:#eef6ff!important}.dpef-query-panel{margin-top:18px;background:#0f172a;color:#e2e8f0;border-radius:16px;padding:16px 18px;display:flex;gap:14px;justify-content:space-between;align-items:flex-start}.dpef-query-panel[hidden]{display:none}.dpef-query-panel code{display:block;white-space:normal;word-break:break-word;margin-top:5px;font-size:13px;color:#f8fafc}.dpef-section-label{font-size:10px;letter-spacing:.1em;font-weight:900;color:#93c5fd}.dpef-copy{flex:0 0 auto;border:1px solid #334155;background:#1e293b;color:#fff;border-radius:9px;padding:9px 12px}.dpef-status{margin:18px 0}.dpef-loading,.dpef-result-head,.dpef-alert{border-radius:14px;padding:15px 18px;background:#fff;border:1px solid var(--line)}.dpef-loading{display:flex;align-items:center;gap:10px}.dpef-spinner{width:19px;height:19px;border-radius:50%;border:3px solid #dbeafe;border-top-color:var(--blue);animation:dpefspin .8s linear infinite}@keyframes dpefspin{to{transform:rotate(360deg)}}.dpef-result-head{display:flex;justify-content:space-between;gap:12px;align-items:center}.dpef-result-head strong{font-size:22px;color:var(--blue)}.dpef-result-head a,.dpef-pubmed-all{color:var(--blue2);font-weight:700;text-decoration:none}.dpef-alert-error{border-color:#fecaca;background:#fff1f2;color:#991b1b}.dpef-results{display:grid;gap:14px}.dpef-card{background:#fff;border:1px solid var(--line);border-radius:18px;padding:22px;box-shadow:0 7px 20px rgba(15,23,42,.045)}.dpef-card-top{display:flex;justify-content:space-between;gap:12px;align-items:center;margin-bottom:8px}.dpef-study{display:inline-flex;background:#e8f3ff;color:var(--blue);font-size:12px;font-weight:900;padding:5px 9px;border-radius:999px}.dpef-pmid{font-size:12px;color:var(--muted)}.dpef-card h2{font-size:20px;line-height:1.35;margin:8px 0}.dpef-card h2 a{color:#172033;text-decoration:none}.dpef-card h2 a:hover{color:var(--blue2)}.dpef-authors{font-size:14px;color:#475569;margin:0 0 5px}.dpef-journal{font-size:13px;color:#64748b;margin:0}.dpef-badges{display:flex;flex-wrap:wrap;gap:6px;margin-top:10px}.dpef-mini-badge{font-size:11px;border:1px solid #d8e1ec;background:#f8fafc;padding:3px 7px;border-radius:999px;color:#475569}.dpef-card-actions{display:flex;align-items:center;flex-wrap:wrap;gap:8px;margin-top:16px}.dpef-card-actions button{border:1px solid #cbd5e1;background:#f8fafc;color:#334155;border-radius:9px;padding:8px 11px;font-size:13px}.dpef-card-actions a{font-size:13px;font-weight:700;color:var(--blue2);text-decoration:none;padding:6px}.dpef-abstract{border-top:1px solid #e2e8f0;margin-top:16px;padding-top:16px}.dpef-abstract p{font-size:14px;color:#334155;white-space:normal}.dpef-citation{margin-top:14px;background:#f8fafc;border-left:4px solid var(--yellow);padding:12px 14px;border-radius:6px;font-size:13px}.dpef-center{text-align:center}.dpef-disclaimer{margin-top:22px;padding:16px 18px;background:#f8fafc;border-radius:14px;color:#64748b;font-size:13px;border:1px solid #e2e8f0}@media(max-width:900px){.dpef-filters{grid-template-columns:1.3fr 1fr 1fr}.dpef-filter-field:last-child{grid-column:1/-1}.dpef-checks{grid-template-columns:1fr 1fr!important}}@media(max-width:800px){.dpef-wrap{margin:14px auto}.dpef-hero{padding:26px 22px;border-radius:18px}.dpef-hero-badge{display:none}.dpef-grid{grid-template-columns:1fr}.dpef-filters{grid-template-columns:1fr 1fr}.dpef-filter-field:last-child{grid-column:auto}.dpef-query-panel{flex-direction:column}.dpef-result-head{align-items:flex-start;flex-direction:column}}@media(max-width:620px){.dpef-filter-section{padding:16px}.dpef-filter-heading span{font-size:12px}.dpef-filters{grid-template-columns:1fr}.dpef-checks{grid-template-columns:1fr!important}.dpef-wrap .dpef-check{padding:10px 11px!important}}@media(max-width:520px){.dpef-form{padding:15px}.dpef-actions{align-items:stretch!important}.dpef-actions button{width:100%!important}.dpef-card{padding:17px}.dpef-card-top{align-items:flex-start}.dpef-hero h1{font-size:36px}}